Observations on the Relation of the Virus Caus- Ing Rabbit Papillomas to the Cancers Deriving Therefrom I. the Influence of Tiie Host Sp~.czes and of Tiie Pathogenic Activity and Concentration of the Virus
نویسنده
چکیده
The carcinomas deriving from the papillomas induced with a virus in domestic rabbits (1) have this virus as their primary cause. The present paper is concerned with the carcinogenic effect of various strains of the virus,--meaning thereby the infective materials procured from the "spontaneous" papillomas of different cottontail rabbits,--and with the influence of the concentration of the inoculum, and the method whereby it is introduced. In corollary certain unusual tumors will be described which have followed upon the papillomatosis engendered by the virus in a cottontail rabbit.
منابع مشابه
OBSERVATIONS ON THE RELATION OF THE VIRUS CAUSING RABBIT PAPILLOMAS TO THE CANCERS DERIVING THEREFROM II. THE EvmENcE PROVIDED BY T~E TU~0gS: GE~'-E~X, CONSIDERATIONS
In an accompanying paper the relationship of the Shope virus engendering papillomas to the cancers deriving from these growths has been approached from the side of the virus. I t will now be considered in the light of certain data provided by the tumors themselves. The papilloma is known to be characterized by those traits of appearance and behavior which distinguish neoplasms from other pathol...
متن کاملObservations on the Relation of the Virus Causing Rabbit Papillomas to the Cancers Deriving Therefrom
The papillomas caused by the Shope virus sometimes grow down spontaneously into the subcutaneous tissue and extend along the lymphatics in the same way as do many cancers of the human breast. They may even invade the voluntary muscle under such circumstances, taking on an aspect suggestive of squamous cell carcinomatosis, but ultimately they differentiate in the way characteristic of the papill...
متن کاملA Sensitive Neutralization Assay for Influenza C Viruses Based on the Acetylesterase Activity HEF Glycoprotein
Influenza C virus possesses specific neuraminate-O-acetylesterase as a receptor-destroying function. This enzymatic activity of the viral glycoprotein HEF (Hemagglutinin, esterase activity and fusion factor) can be visualized in situ by the use of distinct color substrates. Hereby the localization, as well as the quantity of synthesized HEF protein is detectable. We further developed the estera...
متن کاملThe Effect of Herpes Simplex Virus Virion Host Shutoff Gene- a New Suicide Gene- on Tumor Cells
Background: The herpes simplex virus (HSV) UL41 gene product, virion host shutoff (Vhs) protein, mediates the rapid degradation of both viral and cellular mRNA. This ability suggests that Vhs protein can be used as a suicide gene in cancer gene therapy applications. The recent reports have shown that the degradation of cellular mRNA during herpes simplex infection is selective. RNA containing A...
متن کاملSEROLOGICAL REACTIONS WITH A VIRUS CAUSING RAB- BIT PAPILLOMAS WHICH BECOME CANCEROUS I. T~sTs oF THE BLOOD OF ANIMALS CARRYING TIIE PAPILLOMA BY
The cutaneous papillomas induced in domestic rabbits with a virus procured from western cottontails (1) have the immediate attributes of tumors (2), and they frequently become cancerous (3). The problem of the relation of the virus to the neoplastic activities is com-pUcated by a singular difficulty. Though readily obtained from most of the naturally occurring papillomas of cottontails, it cann...
متن کامل